In addition, the growing trend of this disease, its high costs of treatment and hospitalization, and resource constraints prove the need to explore safe, effective, and inexpensive COVID medications for shortening the disease course and enhancing the prognosis. This study will be conducted in accordance with the guidelines of Declaration of Helsinki revision. The independent samples t-test will also be utilized for comparing the changes between the two groups.
Persian manuscripts : ʻajāyib al-makhlūqāt
The of this study have the potential for public health applicability. Some patients also experience loss of taste and smell, headaches, or diarrhea.
The aqueous extract of M. Heart tonic, lung tonic, antitussive, and anti-diarrhea activities are some of the properties mentioned for M. Recent studies demonstrated the antioxidant, anti-inflammatory, anti-viral, and anti-microbial properties of this herb. The efficacy, safety, and availability of the treatment are the key factors indicating the success of any drug in being welcomed.
ly, considerable studies had been deated in the field of CAM for prevention, treatment, and rehabilitation of Severe acute respiratory syndrome SARS and influenza [ 9 ]. At the end of the study, participants will be able to access a copy of the of the trial from the researchers.
A secretary enrolls participants to intervention groups via sequentially ed opaque envelopes. Only the data of participants who complete the follow-up will be considered. Healers with different therapeutic approaches, including classic medicine, herbal medicine, acupuncture, Chinese medicine, and Persian medicine have intent to find a solution to cure or lessen the s and symptoms of this contagious disease [ 78 ].
The outbreak of the pneumonia caused by the novel coronavirus COVID was first observed in Wuhan, Hubei province, China, in December and quickly spread all over the country, and then almost all throughout the world, it formed a global concern as a pandemic [ 12 ].
Metrics details. Patients with mild symptoms may have only fever and fatigue, whereas in severe cases, patients experience shortness of breath, hypoxia, and acute respiratory distress syndrome, which may include severe metabolic acidosis, coagulation disorders, and septic shock.
Early persian medical works on antisyphilitic mercury medicines
Since Decemberthe outbreak of coronavirus pneumonia was observed in China and quickly propagate in all of the world. Int J Antimicrob Agents. The target audience will be reached through oral presentations, publications, and seminars. successful experiences on the efficacy of herbs of traditional Chinese medicine in managing SARS, middle east respiratory syndrome MERSand influenza have resulted in deing various researches on different aspects and capacities of alternative medicine for alleviating COVID disease [ 8 ].
In addition, based on the ancient Persian medicine resources, M. The evaluation of the safety of the plant is very crucial especially in such ificant projects as COVID disease.
Peer Review reports. If the primary sample size is adequate, the study will be finished, and if it is inadequate, the study will be continued under the supervision of the ethics committee of Kerman University of Medical Sciences. Patients clinically suspected to the COVID pneumonia are considered and enrolled as suspected cases if they meet either an epidemiological history and two clinical manifestations or three clinical manifestations without epidemiological history.
This issue is a popular subject raised by both people and health professionals involving the current pandemic. Data and source documents will be archived for the purposes of any need for monitoring or inspection by the Ethics Committee. They would be eligible if they do not have exclusion criteria including pregnancy, lactation, allergy to M. Exclusion criteria further covered recent consumption of herbal drugs. The procedure will be explained to the patients complying with the inclusion criteria, and each participant will voluntarily an informed written consent.
Efficacy of a vaginal tablet as a persian medicine product on vulvovaginal candidiasis: a double-blind, randomised, placebo-controlled trial
All eligible patients will be randomly allocated to intervention and control groups. A team from the Vice-Chancellor for Research monitors the processes. Differences of groups M. The statistical analysis will perform via SPSS However, the Vice-Chancellor for Research and ethics committee of Kerman University of Medical Sciences have supervision on trial and make the final decision to terminate the study.
The present research will provide evidence as to whether M. Myrtus communisas a potent anti-viral agent, may be useful especially in the early stage of the disease [ 15 ]; on the other hand, its anti-inflammatory property can reduce the cytokine storm [ 16 ].
There are no legal, ethical, or security issues related to recording, collection of the data, storage, processing, and dissemination for this trial. Lack of monitoring such laboratory data as inflammatory factors, lymphocyte count, and renal and liver function, as well as the lack of following the chest radiography, are the other limitations of this study.
Their demographic data including gender and age will compare between the two groups using the chi-square test. Hence, an evidence-based clinical trial to evaluate the effectiveness of M. Moreover, based on the of this study, we will hold a large-scale clinical trial, with the aim to comprehensively assess the efficacy and safety of M. The protocol version is two with revision ID: and registration date: June 3, The patient recruitment for this research has begun on April 18, It is expected to continue till July 30, Any modification in coordination with the Ethics Committee will be recorded on Iranian registry of clinical trials web-site.
Myalgia, via visual analog scale VAS [ 13 ]. The efficacy of this herb on diarrhea has been proved in several researches [ 17 ].
It should be noted that high-risk patients are excluded from this study. The compliance of the participants will be evaluated via a telephone survey to record the usage of study medication and any side effects.
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A trained general physician will visit the patients. Hence, it can be concluded that another placebo-controlled study on the confirmed COVID patients is required and ethically justifiable. Trials volume 21Article : Cite this article. Finally, patients who meet eligibility criteria will be invited to the study. They can contact the researchers until a month later in case of any presenting adverse effects.
This study aims at investigating the effect of M. Patients in both groups M. The protocol describes the de of an ongoing randomized controlled trial to establish the evidence for the usage of water extract of M. The will be disseminated through manuscript publications and presentations to scientific meetings.
The protocol of this study was conceived when the PCR test was not adequately available for confirming the diagnosis of COVID infection; on the other hand, the placebo-controlled setting can enhance the value of the study. According to this guideline, the allowed medication for outpatients who are not high risk is supportive care such as acetaminophen, and for those who are high risk is hydroxyl chloroquin sulfate or chloroquine phosphate.
At the onset of clinical symptoms, most patients have such complaints as fever, cough, shortness of breath, muscular pain, and fatigue.
The criteria for discontinuing the trial are allergy or any other adverse effects to M. This open-label randomized controlled clinical trial will be conducted to determine the effect of M. In this trial, the allocation ratio was considered This study will be conducted in the referral clinic of Afzalipour Hospital affiliated to Kerman University of Medical Sciences, Kerman, southeastern Iran.
Hydroxychloroquine and azithromycin as a treatment of COVID of an open-label non-randomized clinical trial. Due to persian dating Myrtle MS lack of a similar study, the primary sample size was initially considered to be 70 35 in each arm [ 14 ]. The researchers obtain written informed consent from the participants, then they are randomly divided into intervention M. Patients in both groups are permitted to take only conventional treatment which are indicated in the fifth edition of the novel coronavirus pneumonia guideline of the Iranian Ministry of Health and Medical Education.
The mortality rate varies in different age groups and under different conditions and underlying diseases, but it is generally not high compared to similar diseases; nevertheless, due to the high probability of transmission of this disease, mortality and economic costs are ificant [ 567 ]. Patients in the intervention group should take M. So, they received packets containing M.
Trained assessors collect data and record them in prepared forms.
Researchers are responsible for providing treatment conditions to eliminate any side effects caused by the intervention. Exploring the clinical trials registered on different World Health Organization Primary Registries proved a notable attention to complementary and alternative medicine CAM for controlling the novel coronavirus pneumonia [ 7 ]. clinical trials on M. On the other hand, M. Therefore, there are no major concerns regarding the possible side effects of a long-term consumption.
Therefore, considering the pharmacological activities of M. The main purpose of the proposed trial is to determine whether M. Primary hypothesis: taking M. The present trial is deed against the uncertainties about the value of applying alternative therapy and herbal medicine for alleviating the symptoms and promoting the prognosis of the mentioned disease.
Cough severityvia Fisman Cough Severity Score, graded as five points 0, 1, 2, 3, 4 varying between 0 no cough and 4 severe cough with chest discomfort [ 12 ]. We will not generate any sensitive data, and also we will not under any confidentiality contract. Nowadays, many trials are underway on this disease in which the efficacy of various therapeutic remedies including chemical or natural agents as well as different non-pharmacological methods such as acupuncture are evaluated.
The test schedule and procedures are provided in Table 1. The infection caused by the novel coronavirus has a wide range from asymptomatic infectious to mild upper respiratory tract disease which may lead to severe pneumonia and even death [ 34 ].