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In addition, patients with a history of severe milk protein allergy that, in the opinion of the study physician, contraindicates the subject's participation will also be excluded.

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Actual Enrollment :. The events that occurred no more than 7 days after the participants last dose of IP are considered as on-treatment adverse events. Gender: Male or female. Being treated for hypercholesterolemia Being treated for hypertension Being treated for diabetes mellitus Being treated for peripheral vascular disease.

On-treatment CV composite event is comprised of the first event that is adjudicated as on-treatment CV death, myocardial infarction, stroke, unstable angina, or transient ischemic attack experienced by a participant.

Epub May Association of platelet count with all-cause mortality and risk of cardiovascular and respiratory morbidity in stable COPD. A hazard ratio less than 1 indicates a lower risk of a first CV event rate versus placebo or any arm. Inclusion Criteria: Type of subject: outpatient. The decision to include or exclude women of childbearing potential may be made at the discretion of the investigator in accordance with local practice in relation to adequate contraception. Affiliation with investigator site: Study investigators, sub-investigators, study coordinators, employees of a participating investigator or immediate family members of the aforementioned are excluded from participating in this study.

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Established i. Epub Apr Fluticasone furoate and vilanterol and survival in chronic obstructive pulmonary disease with heightened cardiovascular risk SUMMIT : a double-blind randomised controlled trial. Erratum in: J Am Coll Cardiol.

FEV1 was fitted as the response variable with treatment group, age, gender, baseline FEV1 and time on treatment as fixed effects.

A hazard ratio of less than 1 indicates a lower death rate versus placebo or other arm. Cox PH Model was adjusted for age, gender and indicators of ischemic and vascular disease, including all four treatment arms.

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Actual Primary Completion Date :. Respir Res. ERJ Open Res. J Am Coll Cardiol. Asthma: Subjects with a current diagnosis of asthma. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or information. Epub Sep National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services.

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Detailed Description:. This model allowed for an initial increase in FEV1, but then tested the difference in slopes from the first post-baseline measurement which was at 3 months. Eligibility Criteria. Phase 3.

Informed consent: Subjects must give their ed and dated written informed consent to participate. smokers are defined as those who have stopped smoking for at least 6 months prior to Visit 1.

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A positive treatment difference indicates a slower rate of decline vs Placebo or Component. The effect of treatment on decline of post bronchodilator FEV1 recorded during the treatment period was analyzed using a particular form of a mixed effect model - a random coefficients model.

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Please refer to this study by its ClinicalTrials. Common end date is the study end date where approximately deaths would have occurred in the ITT-E Population. End stage chronic renal disease: Subjects will be excluded if on renal replacement therapy hemodialysis or peritoneal. Female subjects must be post-menopausal or using a highly effective method for avoidance of pregnancy. Other respiratory disorders: Subjects with active tuberculosis, lung cancer, bronchiectasis, sarcoidosis, pulmonary fibrosis, pulmonary hypertension, interstitial lung diseases or other active pulmonary diseases.

Clin Trials. Lung resection or transplantation: Subjects with lung volume reduction surgery within the 12 months prior to Screening or having had a lung transplant. Read our disclaimer for details. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Contacts and Locations. Talk with your doctor and family members or friends about deciding to a study. Despite a potential link between the pathogenetic mechanisms involved in Chronic Obstructive Pulmonary Disease COPD and atherosclerotic cardiovascular disease, there are no currently approved therapies for patients with COPD that have clearly shown an additional beneficial effect in patients with cardiovascular comorbidities.

Pulmonary Disease, Chronic Obstructive.

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A negative slope indicates a decline. Save this study. FDA Resources.

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Ann Am Thorac Soc. Cigarette smoking and response to inhaled corticosteroids in COPD. TORCH demonstrated a Only deaths which occurred on or before the CED were used for the primary analysis. Drug Information available for: Fluticasone propionate Fluticasone Fluticasone furoate. Eur Respir J. Print Jan. Respir Med. Epub Aug 1. First Posted : August 9, Last Update Posted : August 6, Study Description. Study Type :. Oxygen therapy: Subjects receiving treatment with long-term oxygen therapy LTOT or nocturnal oxygen therapy required for greater than 12 hours a day.

Interventional Clinical Trial. Warning You have reached the maximum of saved studies Listing a study does not mean it has been evaluated by the U. Federal Government.

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Outcome Measures. Subjects with a prior history of asthma are eligible if they also have a current diagnosis of COPD. For general information, Learn About Clinical Studies. Actual Study Start Date :. Oxygen prn use i.

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Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Search for terms.

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More Information. Only participants with at least one on-treatment post-bronchodilator FEV1 measurement were analyzed.

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Arms and Interventions. Post-bronchodilator spirometry will be performed approximately 15 minutes after the subject has self-administered 4 inhalations i. Questionable validity of consent: Subjects with a history of psychiatric disease, intellectual deficiency, poor motivation or other conditions that will limit the validity of informed consent to participate in the study or the potential compliance to study procedures.

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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Time on treatment was treated as a continuous variable. Study record managers: refer to the Data Element Definitions if submitting registration or information.

To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below.